CAR T cell therapy for T cell leukemia and lymphoma: latest updates from 2022 ASH Annual Meeting
Due to the concern of fratricide, clinical development of CAR T cells for the therapy of T cell malignancies lagsbehind that for B cell malignancies. Attempts are being made to revise T cell biomarkers so tha...
Authors: Qiusha Huang, Xiao-hui Zhang and Delong Liu
Citation: Journal of Hematology & Oncology 2023 16:18
Content type: Correspondence Published on: 5 March 2023
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The consensus from The Chinese Society of Hematology on indications, conditioning regimens and donor selection for allogeneic hematopoietic stem cell transplantation: 2021 update
The consensus recommendations in 2018 from The Chinese Society of Hematology (CSH) on indications, conditioning regimens and donor selection for allogeneic hematopoietic stem cell transplantation (allo-HSCT) f...
Authors: Xiao-hui Zhang, Jing Chen, Ming-Zhe Han, He Huang, Er-lie Jiang, Ming Jiang, Yong-rong Lai, Dai-hong Liu, Qi-Fa Liu, Ting Liu, Han-yun Ren, Yong-Ping Song, Zi-min Sun, Xiao-wen Tang, Jian-min Wang, De-pei Wu…
Citation: Journal of Hematology & Oncology 2021 14:145
Content type: Review Published on: 15 September 2021
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Mortality of lymphoma and myeloma in China, 2004–2017: an observational study
There is a dearth of accurate information about patterns of mortality of lymphoid neoplasms and temporal trends in China. In this nationwide mortality study, we aimed to assess the mortality of lymphoma and my...
Authors: Weiping Liu, Jiangmei Liu, Yuqin Song, Xiaopei Wang, Maigeng Zhou, Lijun Wang, Jun Ma and Jun Zhu
Citation: Journal of Hematology & Oncology 2019 12:22
Content type: Research Published on: 4 March 2019
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The consensus on indications, conditioning regimen, and donor selection of allogeneic hematopoietic cell transplantation for hematological diseases in China—recommendations from the Chinese Society of Hematology
Allogeneic hematopoietic stem cell transplantation (allo-HSCT) is widely used to treat malignant hematological neoplasms and non-malignant hematological disorders. Approximately, 5000 allo-HSCT procedures are ...
Authors: Lanping Xu, Hu Chen, Jing Chen, Mingzhe Han, He Huang, Yongrong Lai, Daihong Liu, Qifa Liu, Ting Liu, Ming Jiang, Hanyun Ren, Yongping Song, Zimin Sun, Jianmin Wang, Depei Wu, Daobin Zhou…
Citation: Journal of Hematology & Oncology 2018 11:33
Content type: Review Published on: 2 March 2018
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Recurrent XPO1 mutations alter pathogenesis of chronic lymphocytic leukemia
Exportin 1 (XPO1/CRM1) is a key mediator of nuclear export with relevance to multiple cancers, including chronic lymphocytic leukemia (CLL). Whole exome sequencing has identified hot-spot somatic XPO1 point mutat...
Authors: Janek S. Walker, Zachary A. Hing, Bonnie Harrington, Jordan Baumhardt, Hatice Gulcin Ozer, Amy Lehman, Brian Giacopelli, Larry Beaver, Katie Williams, Jordan N. Skinner, Casey B. Cempre, Qingxiang Sun, Sharon Shacham, Benjamin R. Stromberg, Matthew K. Summers, Lynne V. Abruzzo…
Citation: Journal of Hematology & Oncology 2021 14:17
Content type: Research Published on: 15 January 2021
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Natural killer cells in clinical development as non-engineered, engineered, and combination therapies
Natural killer (NK) cells are unique immune effectors able to kill cancer cells by direct recognition of surface ligands, without prior sensitization. Allogeneic NK transfer is a highly valuable treatment opti...
Authors: Nina Lamers-Kok, Denise Panella, Anna-Maria Georgoudaki, Haiping Liu, Didem Özkazanc, Lucia Kučerová, Adil Doganay Duru, Jan Spanholtz and Monica Raimo
Citation: Journal of Hematology & Oncology 2022 15:164
Content type: Review Published on: 8 November 2022
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Advances in the assessment of minimal residual disease in mantle cell lymphoma
The clinical impact of minimal residual disease detection at early time points or during follow-ups has been shown to accurately predict relapses among patients with lymphomas, mainly in follicular and diffuse...
Authors: Dayoung Jung, Preetesh Jain, Yixin Yao and Michael Wang
Citation: Journal of Hematology & Oncology 2020 13:127
Content type: Review Published on: 24 September 2020
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Novel therapeutic agents for cutaneous T-Cell lymphoma
Mycosis fungoides (MF) and Sezary Syndrome (SS) represent the most common subtypes of primary Cutaneous T-cell lymphoma (CTCL). Patients with advanced MF and SS have a poor prognosis leading to an interest in ...
Authors: Salvia Jain, Jasmine Zain and Owen O’Connor
Citation: Journal of Hematology & Oncology 2012 5:24
Content type: Review Published on: 17 May 2012
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A precision medicine classification for treatment of acute myeloid leukemia in older patients
Older patients (≥ 60years) with acute myeloid leukemia (AML) often have multiple, sequentially acquired ... with poor outcome. Beat AML is a Leukemia and Lymphoma Society-sponsored, multicenter umbrella study th...
Authors: Alice S. Mims, Jessica Kohlschmidt, Uma Borate, James S. Blachly, Shelley Orwick, Ann-Kathrin Eisfeld, Dimitrios Papaioannou, Deedra Nicolet, Krzysztof Mrόzek, Eytan Stein, Bhavana Bhatnagar, Richard M. Stone, Jonathan E. Kolitz, Eunice S. Wang, Bayard L. Powell, Amy Burd…
Citation: Journal of Hematology & Oncology 2021 14:96
Content type: Research Published on: 23 June 2021
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Current trials for frontline therapy of mantle cell lymphoma
Mantle cell lymphoma (MCL) is a rare and incurable subtype of non-Hodgkin’s lymphoma that generally affects older individuals. However, the use of high-dose therapy and autologous stem cell transplant has impr...
Authors: Raphael E. Steiner, Jorge Romaguera and Michael Wang
Citation: Journal of Hematology & Oncology 2018 11:13
Content type: Review Published on: 27 January 2018
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Novel target and treatment agents for natural killer/T-cell lymphoma
The rapidly increasing use of high-throughput screening had produced a plethora of expanding knowledge on the molecular basis of natural killer/T-cell lymphoma (NKTCL), which in turn has revolutionized the tre...
Authors: Xiao-Peng Tian, Yi Cao, Jun Cai, Yu-Chen Zhang, Qi-Hua Zou, Jin-Ni Wang, Yu Fang, Jia-Hui Wang, Song-Bin Guo and Qing-Qing Cai
Citation: Journal of Hematology & Oncology 2023 16:78
Content type: Review Published on: 22 July 2023
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Immune checkpoint blockade and CAR-T cell therapy in hematologic malignancies
Harnessing the power of the immune system to recognize and eliminate cancer cells is a longtime exploration. In the past decade, monoclonal antibody (mAb)-based immune checkpoint blockade (ICB) and chimeric an...
Authors: Hao Wang, Gurbakhash Kaur, Alexander I. Sankin, f*ckiang Chen, Fangxia Guan and Xingxing Zang
Citation: Journal of Hematology & Oncology 2019 12:59
Content type: Review Published on: 11 June 2019
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Mutational profiling of acute lymphoblastic leukemia with testicular relapse
Relapsed acute lymphoblastic leukemia (ALL) is the leading cause of deaths of childhood cancer. Although relapse usually happens in the bone marrow, extramedullary relapse occasionally occurs including either ...
Authors: Ling-Wen Ding, Qiao-Yang Sun, Anand Mayakonda, Kar-Tong Tan, Wenwen Chien, De-Chen Lin, Yan-Yi Jiang, Liang Xu, Manoj Garg, Zhen-Tang Lao, Michael Lill, Henry Yang, Allen Eng Juh Yeoh and H. Phillip Koeffler
Citation: Journal of Hematology & Oncology 2017 10:65
Content type: Letter to the Editor Published on: 2 March 2017
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Preclinical evaluation of combination nemtabrutinib and venetoclax in chronic lymphocytic leukemia
Inhibitors of B cell receptor (BCR) signaling such as the Bruton’s tyrosine kinase (BTK) inhibitors are effective therapeutics for chronic lymphocytic leukemia (CLL). The first-in-class covalent BTK inhibitor,...
Authors: Elizabeth M. Muhowski, Janani Ravikrishnan, Britten Gordon, Lianbo Yu, Shrilekha Misra, Brandi Walker, Sudharshan Eathiraj, Deepa Sampath, Kerry A. Rogers, John C. Byrd and Jennifer A. Woyach
Citation: Journal of Hematology & Oncology 2022 15:166
Content type: Correspondence Published on: 15 November 2022
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Evidence-based expert consensus on the management of primary central nervous system lymphoma in China
Primary central nervous system lymphoma (PCNSL) is a type of central nervous system restricted non-Hodgkin lymphoma, whose histopathological diagnosis is majorly large B cell lymphoma. To provide specific, evi...
Authors: Tong Chen, Yuanbo Liu, Yang Wang, Qing Chang, Jinsong Wu, Zhiliang Wang, Daoying Geng, Jin-Tai Yu, Yuan Li, Xiao-Qiu Li, Hong Chen, Dongxiao Zhuang, Jianyong Li, Bin Wang, Tao Jiang, Lanting Lyu…
Citation: Journal of Hematology & Oncology 2022 15:136
Content type: Review Published on: 29 September 2022
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Clinical significance of cytogenetic aberrations in bone marrow of patients with diffuse large B-cell lymphoma: prognostic significance and relevance to histologic involvement
Although knowledge of the genetics of diffuse large B-cell lymphoma (DLBCL) has been increasing, little is known about the characteristics and prognostic significance of cytogenetic abnormalities and the clini...
Authors: Seon Young Kim, Hyo Jung Kim, Hye Jin Kang, Jin Seok Kim, Hyeon Seok Eom, Tae Min Kim, Sung-Soo Yoon, Cheolwon Suh and Dong Soon Lee
Citation: Journal of Hematology & Oncology 2013 6:76
Content type: Research Published on: 3 October 2013
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Beyond Bruton’s tyrosine kinase inhibitors in mantle cell lymphoma: bispecific antibodies, antibody–drug conjugates, CAR T-cells, and novel agents
Mantle cell lymphoma is a B cell non-Hodgkin lymphoma (NHL), representing 2–6% of all NHLs and characterized by overexpression of cyclin D1. The last decade has seen the development of many novel treatment app...
Authors: Neeraj Jain, Mukesh Mamgain, Sayan Mullick Chowdhury, Udita Jindal, Isha Sharma, Lalit Sehgal and Narendranath Epperla
Citation: Journal of Hematology & Oncology 2023 16:99
Content type: Review Published on: 25 August 2023
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Maintenance therapy in acute myeloid leukemia after allogeneic hematopoietic stem cell transplantation
Relapse remains the main cause of treatment failure in acute myeloid leukemia (AML) undergoing allogeneic hematopoietic stem cell transplantation (allo-HSCT). Emerging evidence has demonstrated that AML patien...
Authors: Li Xuan and Qifa Liu
Citation: Journal of Hematology & Oncology 2021 14:4
Content type: Review Published on: 6 January 2021
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Unresolved questions in selection of therapies for treatment-naïve chronic lymphocytic leukemia
The treatment landscape for chronic lymphocytic leukemia (CLL) continues to undergo considerable evolution. Optimal selection of initial therapy from multiple effective options provides a major challenge for c...
Authors: Rory Bennett, Mary Ann Anderson and John F. Seymour
Citation: Journal of Hematology & Oncology 2023 16:72
Content type: Review Published on: 8 July 2023
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Update in the management of chronic lymphocytic leukemia
Advances in the treatment of chronic lymphocytic leukemia (CLL) have improved initial overall response (OR) rates, complete response (CR) rates and progression free survival (PFS). Despite these advances, CLL ...
Authors: Kami J Maddocks and Thomas S Lin
Citation: Journal of Hematology & Oncology 2009 2:29
Content type: Review Published on: 20 July 2009
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Treatment of mantle cell lymphoma in Asia: a consensus paper from the Asian Lymphoma Study Group
Mantle cell lymphoma (MCL) is a B cell malignancy that can be aggressive and with a poor prognosis; the clinical course is heterogeneous. The epidemiology of MCL in Asia is not well documented but appears to c...
Authors: Dok Hyun Yoon, Junning Cao, Tsai-Yun Chen, Koji Izutsu, Seok Jin Kim, Yok Lam Kwong, Tong Yu Lin, Lim Soon Thye, Bing Xu, Deok Hwan Yang and Won Seog Kim
Citation: Journal of Hematology & Oncology 2020 13:21
Content type: Review Published on: 17 March 2020
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Post-transplant cyclophosphamide after matched sibling, unrelated and haploidentical donor transplants in patients with acute myeloid leukemia: a comparative study of the ALWP EBMT
The use of post-transplant cyclophosphamide (PTCy) is highly effective in preventing graft-versus-host disease (GVHD) in the haploidentical (Haplo) transplant setting and is being increasingly used in matched ...
Authors: Jaime Sanz, Jacques-Emmanuel Galimard, Myriam Labopin, Boris Afanasyev, Emanuele Angelucci, Fabio Ciceri, Didier Blaise, Jan J. Cornelissen, Ellen Meijer, J. L. Diez-Martin, Yener Koc, Montserrat Rovira, Luca Castagna, Bipin Savani, Annalisa Ruggeri, Arnon Nagler…
Citation: Journal of Hematology & Oncology 2020 13:46
Content type: Research Published on: 6 May 2020
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New targets for the treatment of follicular lymphoma
The last two decades have witnessed striking advances in our understanding of the biological factors underlying the development of Follicular lymphoma (FL). Development of newer treatment approaches have impro...
Authors: Nishant Tageja, Subhash Padheye, Prasad Dandawate, Ayad Al-Katib and Ramzi M Mohammad
Citation: Journal of Hematology & Oncology 2009 2:50
Content type: Review Published on: 23 December 2009
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Thrombotic and bleeding complications in patients with chronic lymphocytic leukemia and severe COVID-19: a study of ERIC, the European Research Initiative on CLL
Patients with chronic lymphocytic leukemia (CLL) may be more susceptible to COVID-19 related poor outcomes, including thrombosis and death, due to the advanced age, the presence of comorbidities, and the disea...
Authors: Darko Antic, Natasa Milic, Thomas Chatzikonstantinou, Lydia Scarfò, Vladimir Otasevic, Nina Rajovic, David Allsup, Alejandro Alonso Cabrero, Martin Andres, Monica Baile Gonzales, Antonella Capasso, Rosa Collado, Raul Cordoba, Carolina Cuéllar-García, Juan Gonzalo Correa, Lorenzo De Paoli…
Citation: Journal of Hematology & Oncology 2022 15:116
Content type: Research Published on: 26 August 2022
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Mosunetuzumab and lymphoma: latest updates from 2022 ASH annual meeting
Bispecific antibodies are emerging as a promising new immunotherapy modality and are actively being evaluated in clinical trials for patients with lymphoma. As the first BsAb to receive regulatory approval for...
Authors: Yang Cao, Emanuela C. Marcucci and Lihua E. Budde
Citation: Journal of Hematology & Oncology 2023 16:69
Content type: Correspondence Published on: 28 June 2023
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Advances in CD30- and PD-1-targeted therapies for classical Hodgkin lymphoma
CD30 and programmed cell death protein 1 (PD-1) are two ideal therapeutic targets in classical Hodgkin lymphoma (cHL). The CD30 antibody-drug conjugate (ADC) brentuximab vedotin and the PD-1 antibodies nivolum...
Authors: Yucai Wang, Grzegorz S. Nowakowski, Michael L. Wang and Stephen M. Ansell
Citation: Journal of Hematology & Oncology 2018 11:57
Content type: Review Published on: 23 April 2018
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Burden of lymphoma in China, 2006–2016: an analysis of the Global Burden of Disease Study 2016
The accurate information about lymphoma burden at national and provincial levels remains unknown in China.
Authors: Weiping Liu, Jiangmei Liu, Yuqin Song, Xinying Zeng, Xiaopei Wang, Lan Mi, Cai Cai, Lijun Wang, Jun Ma and Jun Zhu
Citation: Journal of Hematology & Oncology 2019 12:115
Content type: Research Published on: 19 November 2019
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Allogeneic stem cell transplantation for peripheral T cell lymphomas: a retrospective study in 285 patients from the Société Francophone de Greffe de Moelle et de Thérapie Cellulaire (SFGM-TC)
Peripheral T cell lymphomas form a heterogeneous group with a usually dismal prognostic. The place of allogeneic stem cell transplantation to treat PTCL is debated.
Authors: Anne-Claire Mamez, Axelle Dupont, Didier Blaise, Patrice Chevallier, Edouard Forcade, Patrice Ceballos, Mohamad Mohty, Felipe Suarez, Yves Beguin, Regis Peffault De Latour, Marie-Thérèse Rubio, Olivier Tournilhac and Stéphanie Nguyen
Citation: Journal of Hematology & Oncology 2020 13:56
Content type: Research Published on: 19 May 2020
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Ganoderma lucidum polysaccharides can induce human monocytic leukemia cells into dendritic cells with immuno-stimulatory function
Previous studies demonstrated Ganoderma lucidum polysaccharides (GL-PS), a form of bioactive β-glucan can stimulate the maturation of monocyte-derived dendritic cells (DC). The question of how leukemic cells espe...
Authors: Wing Keung Chan, Christopher Ching Hang Cheung, Helen Ka Wai Law, Yu Lung Lau and Godfrey Chi Fung Chan
Citation: Journal of Hematology & Oncology 2008 1:9
Content type: Research Published on: 21 July 2008
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Targeting MYC activity in double-hit lymphoma with MYC and BCL2 and/or BCL6 rearrangements with epigenetic bromodomain inhibitors
Double/triple-hit lymphomas (DHL/THL) account for 5–10% of diffuse large B cell lymphoma (DLBCL) with rearrangement of MYC and BCL2 and/or BCL6 resulting in MYC overexpression. Despite the poor prognosis of DHL, ...
Authors: Weiping Li, Shiv K. Gupta, Weiguo Han, Ryan A. Kundson, Sara Nelson, Darlene Knutson, Patricia T. Greipp, Sherine F. Elsawa, Eduardo M. Sotomayor and Mamta Gupta
Citation: Journal of Hematology & Oncology 2019 12:73
Content type: Rapid communication Published on: 9 July 2019
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Targeting macrophages in hematological malignancies: recent advances and future directions
Emerging evidence indicates that the detection and clearance of cancer cells via phagocytosis induced by innate immune checkpoints play significant roles in tumor-mediated immune escape. The most well-describe...
Authors: Wei Li, Fang Wang, Rongqun Guo, Zhilei Bian and Yongping Song
Citation: Journal of Hematology & Oncology 2022 15:110
Content type: Review Published on: 17 August 2022
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Identifying long-term survivors and those at higher or lower risk of relapse among patients with cytogenetically normal acute myeloid leukemia using a high-dimensional mixture cure model
Patients with cytogenetically normal acute myeloid leukemia (CN-AML) may harbor prognostically relevant gene mutations and thus be categorized into one of the three 2022 European LeukemiaNet (ELN) genetic-risk...
Authors: Kellie J. Archer, Han Fu, Krzysztof Mrózek, Deedra Nicolet, Alice S. Mims, Geoffrey L. Uy, Wendy Stock, John C. Byrd, Wolfgang Hiddemann, Jan Braess, Karsten Spiekermann, Klaus H. Metzeler, Tobias Herold and Ann-Kathrin Eisfeld
Citation: Journal of Hematology & Oncology 2024 17:28
Content type: Correspondence Published on: 3 May 2024
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Global, regional, and national cancer incidence and death for 29 cancer groups in 2019 and trends analysis of the global cancer burden, 1990–2019
Cancer will soon become the leading cause of death in every country in the twenty-first century. This study aimed to analyze the mortality and morbidity of 29 types of cancer in 204 countries or regions from 1...
Authors: Longfei Lin, Zhiyong Li, Lei Yan, Yuling Liu, Hongjun Yang and Hui Li
Citation: Journal of Hematology & Oncology 2021 14:197
Content type: Research Published on: 22 November 2021
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Functional and genetic screening of acute myeloid leukemia associated with mediastinal germ cell tumor identifies MEK inhibitor as an active clinical agent
Hematologic malignancies arising in the setting of established germ cell tumors have been previously described and have a dismal prognosis. Identification of targetable mutations and pathway dysregulation thro...
Authors: Jessica T. Leonard, Philipp W. Raess, Jennifer Dunlap, Brandon Hayes-Lattin, Jeffrey W. Tyner and Elie Traer
Citation: Journal of Hematology & Oncology 2016 9:31
Content type: Case report Published on: 31 March 2016
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Impact of hematologic malignancy and type of cancer therapy on COVID-19 severity and mortality: lessons from a large population-based registry study
Patients with cancer have been shown to have a higher risk of clinical severity and mortality compared to non-cancer patients with COVID-19. Patients with hematologic malignancies typically are known to have h...
Authors: Julio García-Suárez, Javier de la Cruz, Ángel Cedillo, Pilar Llamas, Rafael Duarte, Víctor Jiménez-Yuste, José Ángel Hernández-Rivas, Rodrigo Gil-Manso, Mi Kwon, Pedro Sánchez-Godoy, Pilar Martínez-Barranco, Blanca Colás-Lahuerta, Pilar Herrera, Laurentino Benito-Parra, Adrián Alegre, Alberto Velasco…
Citation: Journal of Hematology & Oncology 2020 13:133
Content type: Research Published on: 8 October 2020
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Survival among patients with relapsed/refractory diffuse large B cell lymphoma treated with single-agent selinexor in the SADAL study
Patients with RR DLBCL who have received ≥ 2 lines of therapy have limited treatment options and an expected overall survival (OS) of < 6months. The SADAL study evaluated single-agent oral selinexor in patien...
Authors: Marie Maerevoet, Josee M. Zijlstra, George Follows, Rene-Olivier Casasnovas, J. S. P. Vermaat, Nagesh Kalakonda, Andre Goy, Sylvain Choquet, Eric Van Den Neste, Brian Hill, Catherine Thieblemont, Federica Cavallo, Fatima De la Cruz, John Kuruvilla, Nada Hamad, Ulrich Jaeger…
Citation: Journal of Hematology & Oncology 2021 14:111
Content type: Letter to the Editor Published on: 16 July 2021
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Conventional and novel [18F]FDG PET/CT features as predictors of CAR-T cell therapy outcome in large B-cell lymphoma
Relapse and toxicity limit the effectiveness of chimeric antigen receptor T-cell (CAR-T) therapy for large B-cell lymphoma (LBCL), yet biomarkers that predict outcomes and toxicity are lacking. We examined rad...
Authors: Doris Leithner, Jessica R. Flynn, Sean M. Devlin, Audrey Mauguen, Teng Fei, Shang Zeng, Junting Zheng, Brandon S. Imber, Harper Hubbeling, Marius E. Mayerhoefer, Akshay Bedmutha, Efrat Luttwak, Magdalena Corona, Parastoo B. Dahi, Alejandro Luna de Abia, Ivan Landego…
Citation: Journal of Hematology & Oncology 2024 17:21
Content type: Correspondence Published on: 23 April 2024
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COVID-19 infection in adult patients with hematological malignancies: a European Hematology Association Survey (EPICOVIDEHA)
Patients with hematological malignancies (HM) are at high risk of mortality from SARS-CoV-2 disease 2019 (COVID-19). A better understanding of risk factors for adverse outcomes may improve clinical management ...
Authors: Livio Pagano, Jon Salmanton-García, Francesco Marchesi, Alessandro Busca, Paolo Corradini, Martin Hoenigl, Nikolai Klimko, Philipp Koehler, Antonio Pagliuca, Francesco Passamonti, Luisa Verga, Benjamin Víšek, Osman Ilhan, Gianpaolo Nadali, Barbora Weinbergerová, Raúl Córdoba-Mascuñano…
Citation: Journal of Hematology & Oncology 2021 14:168
Content type: Research Published on: 14 October 2021
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Targeting histone methylation for cancer therapy: enzymes, inhibitors, biological activity and perspectives
Post-translational methylation of histone lysine or arginine residues plays important roles in gene regulation and other physiological processes. Aberrant histone methylation caused by a gene mutation, translo...
Authors: Yongcheng Song, Fangrui Wu and Jingyu Wu
Citation: Journal of Hematology & Oncology 2016 9:49
Content type: Review Published on: 17 June 2016
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Notch1-induced T cell leukemia can be potentiated by microenvironmental cues in the spleen
Leukemia is a systemic malignancy originated from hematopoietic cells. The extracellular environment has great impacts on the survival, proliferation and dissemination of leukemia cells. The spleen is an impor...
Authors: Shihui Ma, Yingxu Shi, Yakun Pang, Fang Dong, Hui Cheng, Sha Hao, Jing Xu, Xiaofan Zhu, Weiping Yuan, Tao Cheng and Guoguang Zheng
Citation: Journal of Hematology & Oncology 2014 7:71
Content type: Research Published on: 4 November 2014
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IGF binding protein 2 is a cell-autonomous factor supporting survival and migration of acute leukemia cells
The role of IGF binding protein 2 (IGFBP2) in cancer development is intriguing. Previously we identified IGFBP2 as an extrinsic factor that supports the activity of hematopoietic stem cells (HSCs).
Authors: Xiaoli Chen, Junke Zheng, Yizhou Zou, Chun Song, Xuemei Hu and Cheng Cheng Zhang
Citation: Journal of Hematology & Oncology 2013 6:72
Content type: Research Published on: 8 October 2013
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Targeting Bruton tyrosine kinase using non-covalent inhibitors in B cell malignancies
B cell receptor (BCR) signaling is involved in the pathogenesis of B cell malignancies. Activation of BCR signaling promotes the survival and proliferation of malignant B cells. Bruton tyrosine kinase (BTK) is...
Authors: Danling Gu, Hanning Tang, Jiazhu Wu, Jianyong Li and Yi Miao
Citation: Journal of Hematology & Oncology 2021 14:40
Content type: Review Published on: 6 March 2021
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Role of CD47 in Hematological Malignancies
CD47, or integrin-associated protein, is a cell surface ligand expressed in low levels by nearly all cells of the body. It plays an integral role in various immune responses as well as autoimmunity, by sending...
Authors: Entsar Eladl, Rosemarie Tremblay-LeMay, Nasrin Rastgoo, Rumina Musani, Wenming Chen, Aijun Liu and Hong Chang
Citation: Journal of Hematology & Oncology 2020 13:96
Content type: Review Published on: 16 July 2020
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Targeting p53 by small molecules in hematological malignancies
p53 is a powerful tumor suppressor and is an attractive cancer therapeutic target. A breakthrough in cancer research came from the discovery of the drugs which are capable of reactivating p53 function. Most an...
Authors: Manujendra N Saha, Lugui Qiu and Hong Chang
Citation: Journal of Hematology & Oncology 2013 6:23
Content type: Review Published on: 27 March 2013
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IGF-IR determines the fates of BCR/ABL leukemia
The tyrosine kinase receptor insulin-like growth factor 1 receptor (IGF-IR) contributes to the initiation and progression of many types of malignancies. We previously showed that IGF-2, which binds IGF-IR, is ...
Authors: Jingjing Xie, Xiaoli Chen, Junke Zheng, Chunling Li, Satomi Stacy, Martin Holzenberger, Xuemei Hu and Cheng Cheng Zhang
Citation: Journal of Hematology & Oncology 2015 8:3
Content type: Research Published on: 4 February 2015
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Allogeneic hematopoietic cell transplantation provides effective salvage despite refractory disease or failed prior autologous transplant in angioimmunoblastic T-cell lymphoma: a CIBMTR analysis
There is a paucity of data on the role of allogeneic hematopoietic cell transplantation (allo-HCT) in patients with angioimmunoblastic T-cell lymphoma (AITL). Using the CIBMTR registry, we report here the outc...
Authors: Narendranath Epperla, Kwang W. Ahn, Carlos Litovich, Sairah Ahmed, Minoo Battiwalla, Jonathon B. Cohen, Parastoo Dahi, Nosha Farhadfar, Umar Farooq, Cesar O. Freytes, Nilanjan Ghosh, Bradley Haverkos, Alex Herrera, Mark Hertzberg, Gerhard Hildebrandt, David Inwards…
Citation: Journal of Hematology & Oncology 2019 12:6
Content type: Research Published on: 10 January 2019
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MDM2/X inhibitors under clinical evaluation: perspectives for the management of hematological malignancies and pediatric cancer
The two murine double minute (MDM) family members MDM2 and MDMX are at the center of an intense clinical assessment as molecular target for the management of cancer. Indeed, the two proteins act as regulators ...
Authors: Veronica Tisato, Rebecca Voltan, Arianna Gonelli, Paola Secchiero and Giorgio Zauli
Citation: Journal of Hematology & Oncology 2017 10:133
Content type: Review Published on: 3 July 2017
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BTK inhibitors in the treatment of hematological malignancies and inflammatory diseases: mechanisms and clinical studies
Bruton’s tyrosine kinase (BTK) is an essential component of multiple signaling pathways that regulate B cell and myeloid cell proliferation, survival, and functions, making it a promising therapeutic target fo...
Authors: Aqu Alu, Hong Lei, Xuejiao Han, Yuquan Wei and Xiawei Wei
Citation: Journal of Hematology & Oncology 2022 15:138
Content type: Review Published on: 1 October 2022
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SMI of Bcl-2 TW-37 is active across a spectrum of B-cell tumors irrespective of their proliferative and differentiation status
The Bcl-2 family of proteins is critical to the life and death of malignant B-lymphocytes. Interfering with their activity using small-molecule inhibitors (SMI) is being explored as a new therapeutic strategy ...
Authors: Ayad M Al-Katib, Yuan Sun, Anton Scott Goustin, Asfar Sohail Azmi, Ben Chen, Amro Aboukameel and Ramzi M Mohammad
Citation: Journal of Hematology & Oncology 2009 2:8
Content type: Research Published on: 16 February 2009
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Bispecific T cell engagers: an emerging therapy for management of hematologic malignancies
Harnessing the power of immune cells, especially T cells, to enhance anti-tumor activities has become a promising strategy in clinical management of hematologic malignancies. The emerging bispecific antibodies...
Authors: Zheng Tian, Ming Liu, Ya Zhang and Xin Wang
Citation: Journal of Hematology & Oncology 2021 14:75
Content type: Review Published on: 3 May 2021
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