Cost-effectiveness of adding oseltamivir to primary care for influenza-like-illness: economic evaluation alongside the randomised controlled ALIC4E trial in 15 European countries - Peeref (2024)

Article Rheumatology

Comparing cost-utility of DMARDs in autoantibody-negative rheumatoid arthritis patients

Luurssen-Masurel Nathalie, Van Elise Mulligen, Weel Angelique Elisabeth Adriana Maria, Hazes Johanna Maria Wilhelmina, de Jong Pascal Hendrik Pieter

Summary: This study evaluated the 1-year cost-effectiveness of three different initial treatment strategies in autoantibody-negative RA patients, with iHCQ showing the highest probability of cost-effectiveness and lower healthcare costs but higher productivity costs. However, further validation is needed.

Review Pharmacology & Pharmacy

Cost-effectiveness of janus kinase inhibitors for rheumatoid arthritis: A systematic review and meta-analysis of cost-utility studies

S. Sajith Kumar, Madhumitha Haridoss, Krishnamurthy Venkataraman, Bhavani Shankara Bagepally

Summary: This study found that Janus kinase inhibitors (JAK-i) are cost-effective as a second-line treatment for rheumatoid arthritis (RA) after csDMARD failure, but not cost-effective after csDMARD-TNF-a-i failure.

Article Endocrinology & Metabolism

Cost-Utility of Acromegaly Pharmacological Treatments in a French Context

Thierry Brue, Philippe Chanson, Patrice Rodien, Brigitte Delemer, Delphine Drui, Lucile Marie, Laurene Juban, Lara Salvi, Robin Henocque, Gerald Raverot

Summary: The study aimed to estimate the cost-utility of second-line pharmacological treatments in acromegaly patients.The incremental cost-utility ratios for pasireotide, pegvisomant, and pegvisomant + FGSA were estimated, showing pasireotide to be the least cost-efficient treatment option.

Article Pharmacology & Pharmacy

Alpha emitter radium-223 in patients with metastatic castration-resistant prostate cancer: A cost-utility analysis

Xiaohui Zeng, Qiao Liu, Chongqing Tan, Xiaomin Wan, Yunhua Wang, Xiaowei Ma

Summary: This study assessed the cost effectiveness of radium-223 dichloride for Chinese patients with mCRPC. The results suggest that radium-223 may not be cost effective for patients with bone mCRPC from the perspective of the Chinese health system.

Article Food Science & Technology

Retrospective cost-utility analysis of the Non-typhoidal Salmonella control programme in Hungary

Erika Orszagh, Janos Gyorgy Pitter, Zoltan Kalo, Zoltan Voko, Akos Jozwiak

Summary: This study conducted a cost-utility analysis of the Hungarian Salmonella Control Programme and found that it was cost-effective for the investigated time period. The results can serve as a model for further analyses related to other pathogens or interventions, aiding in the priority setting and decision-making processes of food safety in Hungary.

Article Environmental Sciences

Cost-effective adaptation strategies to rising river flood risk in Europe

Francesco Dottori, Lorenzo Mentaschi, Alessandra Bianchi, Lorenzo Alfieri, Luc Feyen

Summary: River flood risk in Europe could increase due to global warming and development, but implementing adaptation strategies such as detention areas and dyke strengthening could significantly reduce the risk and damage. Detention areas, in particular, are the most economically attractive option, with the potential to lower flood losses by billions of euros per year and decrease the population at risk. Although building-based flood proofing and relocation measures are less cost-effective, they can still mitigate localized impacts.

Article Health Care Sciences & Services

The Cost and the Value of Stroke Care in Greece: Results from the SUN4P Study

Olga Siskou, Petros Galanis, Olympia Konstantakopoulou, Panagiotis Stafylas, Iliana Karagkouni, Evangelos Tsampalas, Dafni Garefou, Helen Alexopoulou, Anastasia Gamvroula, Maria Lypiridou, Ioannis Kalliontzakis, Anastasia Fragkoulaki, Aspasia Kouridaki, Argyro Tountopoulou, Ioanna Kouzi, Sofia Vassilopoulou, Efstathios Manios, Georgios Mavraganis, Anastasia Vemmou, Efstathia Karagkiozi, Christos Savopoulos, Gregorios Dimas, Athina Myrou, Haralampos Milionis, Georgios Siopis, Hara Evaggelou, Athanasios Protogerou, Stamatina Samara, Asteria Karapiperi, Nikolaos Kakaletsis, George Papastefanatos, Stefanos Papastefanatos, Panayota Sourtzi, George Ntaios, Konstantinos Vemmos, Eleni Korompoki, Daphne Kaitelidou

Summary: The study aims to measure the one-year total cost of strokes and investigate the value of stroke care. The findings reveal the significant burden of stroke on the society and emphasize the importance of reorganizing stroke care and promoting cost-effective interventions.

Article Oncology

Cost-Utility Analysis of Open Radical Hysterectomy Compared to Minimally Invasive Radical Hysterectomy for Early-Stage Cervical Cancer

Nadav Michaan, Moshe Leshno, Gil Fire, Tamar Safra, Michal Rosenberg, Shira Peleg-Hasson, Dan Grisaru, Ido Laskov

Summary: This study compares the cost-effectiveness of open surgery versus minimally invasive radical hysterectomy for early-stage cervical cancer, and finds that open radical hysterectomy is both oncologically superior and more cost-effective.

Article Psychiatry

Cost-utility analysis of esketamine and electroconvulsive therapy in adults with treatment-resistant depression

Kinza Degerlund Maldi, Peter Asellus, Anna Myleus, Fredrik Norstrom

Summary: The study shows that from a cost-effectiveness perspective, electroconvulsive therapy (ECT) should be the first-hand option for individuals with treatment-resistant depression (TRD). In contrast, esketamine is more costly and less effective compared to ECT.

Article Economics

Measuring the Indirect Cost of Illness Using EQ-5D-5L While Accounting for Job Characteristics

Beata Kon, Michal Jakubczyk

Summary: This study aimed to assess the impact of job characteristics on health-related absenteeism and presenteeism. It found that health problems were associated with both absenteeism and presenteeism, and job characteristics had different effects on these outcomes.

Article Engineering, Biomedical

Cost Utility of Transcatheter Aortic Valve Replacement: Sapien 3 Versus CoreValve Evolut R

David Posawatz, Joshua Bloom, Alison Massed, Abhishek Chatterjee, Charles Resor, Yong Zhan, Andrew Weintraub, Masashi Kawabori

Summary: TAVR has become the preferred treatment for severe aortic stenosis, but there is a lack of cost-utility comparison between TAVR valves. This study compared the Sapien 3 and CoreValve Evolut R valves using cost-utility analysis and found that although S3 was more expensive, it was more effective and therefore the more cost-effective option.

Article Oncology

Cost-analysis of robot-assisted radical cystectomy in Europe: A cross-country comparison

Georges Mjaess, Romain Diamand, Fouad Aoun, Gregoire Assenmacher, Christophe Assenmacher, Gregory Verhoest, Serge Holz, Michel Naudin, Guillaume Ploussard, Andrea Mari, Andrea Tay, Rami Issa, Mathieu Roumiguie, Anne Sophie Bajeot, Paolo Umari, Ashwin Sridhar, John Kelly, Kees Hendricksen, Sarah Einerhand, Laura S. Mertens, Rafael Sanchez-Salas, Anna Colomer Gallardo, Thierry Quackels, Alexandre Peltier, Benjamin Pradere, Marco Moschini, Thierry Roumeguere, Simone Albisinni

Summary: This study conducted a multicentric cost-analysis of robotic-assisted radical cystectomy (RARC) across hospitals in four European countries. The study found significant variations in the overall cost of RARC among the included countries, which were primarily influenced by hospital length-of-stay and operative time rather than robotic instrumentation.

Article Radiology, Nuclear Medicine & Medical Imaging

FDG-PET/CT in indeterminate thyroid nodules: cost-utility analysis alongside a randomised controlled trial

Elizabeth J. de Koster, Dennis Vriens, Maarten O. van Aken, Lioe-Ting Dijkhorst-Oei, Wim J. G. Oyen, Robin P. Peeters, Abbey Schepers, Lioe-Fee De Geus-Oei, Wilbert B. van den Hout

Summary: This study evaluates the cost-effectiveness of an [F-18]FDG-PET/CT-driven diagnostic workup compared to diagnostic surgery for thyroid nodules with Bethesda III/IV cytology. The results show that [F-18]FDG-PET/CT avoids unnecessary diagnostic surgeries and reduces costs while maintaining quality of life.

Article Pediatrics

Cost-Utility Analysis of Wide-Field Imaging as an Auxiliary Technology for Retinopathy of Prematurity Care in Brazil

Luiza M. Neves, Lorena M. Haefeli, Andrea A. Zin, Ricardo E. Steffen, Zilton F. M. Vasconcelos, Marcia Pinto

Summary: The study evaluated the cost-utility of wide-field imaging as a complementary technology for retinopathy of prematurity screening from the Brazilian Unified Health System's perspective. The combined screening strategy was found to be cost-effective, improving ROP screening coverage and reducing opportunity costs compared to using indirect binocular ophthalmoscopy alone.

Article Clinical Neurology

An economic evaluation of the NightWatch for children with refractory epilepsy: Insight into the cost-effectiveness and cost-utility

Anouk Engelgeer, Anouk van Westrhenen, Roland D. Thijs, Silvia M. A. A. Evers

Summary: This study conducted an economic evaluation of a wearable multimodal seizure detection device, NightWatch, from a societal perspective. The results suggest that NightWatch may be a cost-effective addition to standard care for children with refractory epilepsy living at home.

Article Mathematical & Computational Biology

A spatial model to jointly analyze self-reported survey data of COVID-19 symptoms and official COVID-19 incidence data

Maren Vranckx, Christel Faes, Geert Molenberghs, Niel Hens, Philippe Beutels, Pierre Van Damme, Jan Aerts, Oana Petrof, Koen Pepermans, Thomas Neyens

Summary: This study presents a framework for improving estimation of the spatial distribution of COVID-19 incidence in Belgium using a joint spatial modeling approach. The results show that an online survey can provide valuable auxiliary data to optimize the estimation based on confirmed cases. Additionally, the survey is capable of identifying locations with similar clusters of cases approximately 1 week earlier.

Article Primary Health Care

Post-consultation acute respiratory tract infection recovery: a latent class-informed analysis of individual patient data

Hilda Hounkpatin, Beth Stuart, Shihua Zhu, Guiqing Yao, Michael Moore, Christin Loeffler, Paul Little, Timothy Kenealy, David Gillespie, Nick A. Francis, Jennifer Bostock, Taeko Becque, Bruce Arroll, Attila Altiner, Pablo Alonso-Coello, Alastair D. Hay

Summary: This study analyzed data from 12 primary care studies involving 9103 adults and children, and found that 90% of participants recovered from all symptoms within 28 days, regardless of antibiotic use. For respiratory tract infections with cough as the dominant symptom, four different symptom trajectories were identified, including rapid recovery, intermediate recovery, slow progressive improvement, and slow improvement with initial high symptom burden. Patients with longer duration of cough symptoms were more likely to have re-consultations and hospital admissions.

Article Medicine, General & Internal

Molnupiravir plus usual care versus usual care alone as early treatment for adults with COVID-19 at increased risk of adverse outcomes (PANORAMIC): an open-label, platform-adaptive randomised controlled trial

Christopher C. Butler, F. D. Richard Hobbs, Oghenekome A. Gbinigie, Najib M. Rahman, Gail Hayward, Duncan B. Richards, Jienchi Dorward, David M. Lowe, Joseph F. Standing, Judith Breuer, Saye Khoo, Stavros Petrou, Kerenza Hood, Jonathan S. Nguyen-Van-Tam, Mahendra G. Patel, Benjamin R. Saville, Joe Marion, Emma Ogburn, Julie Allen, Heather Rutter, Nick Francis, Nicholas P. B. Thomas, Philip Evans, Melissa Dobson, Tracie-Ann Madden, Jane Holmes, Victoria Harris, May Ee Png, Mark Lown, Oliver van Hecke, Michelle A. Detry, Christina T. Saunders, Mark Fitzgerald, Nicholas S. Berry, Lazaro Mwandigha, Ushma Galal, Sam Mort, Bhautesh D. Jani, Nigel D. Hart, Haroon Ahmed, Daniel Butler, Micheal McKenna, Jem Chalk, Layla Lavallee, Elizabeth Hadley, Lucy Cureton, Magdalena Benysek, Monique Andersson, Maria Coates, Sarah Barrett, Clare Bateman, Jennifer C. Davies, Ivy Raymundo-Wood, Andrew Ustianowski, Andrew Carson-Stevens, Ly-Mee Yu, Paul Little

Summary: This study aimed to determine the safety, effectiveness, and cost-effectiveness of molnupiravir in vaccinated high-risk patients in the community. The results showed that molnupiravir did not reduce hospital admissions or deaths associated with COVID-19 compared to usual care in this population.

Article Primary Health Care

Initial symptoms and three months follow-up after acute COVID-19 in outpatients: An international prospective cohort study

Katarina Hedin, Alike W. van der Velden, Malene Plejdrup Hansen, Anna B. Moberg, Anca Balan, Pascale Bruno, Samuel Coenen, Eskild Johansen, Anna Kowalczyk, Peter Konstantin Kurotschka, Sanne R. van der Linde, Lile Malania, Jorn Rohde, Jan Verbakel, Heike Vornhagen, Akke Vellinga

Summary: This study conducted a long-term follow-up of non-hospitalized patients with COVID-19 and found that 52% of patients developed long-COVID. The most common symptom was fatigue, and these lingering symptoms had an impact on patients' daily activities. Obese patients took longer to recover compared to non-obese patients.

Article Biotechnology & Applied Microbiology

Development of a live biotherapeutic throat spray with lactobacilli targeting respiratory viral infections

Irina Spacova, Ilke De Boeck, Eline Cauwenberghs, Lize Delanghe, Peter A. Bron, Tim Henkens, Alix Simons, Imane Gamgami, Leentje Persoons, Ingmar Claes, Marianne F. L. van den Broek, Dominique Schols, Peter Delputte, Samuel Coenen, Veronique Verhoeven, Sarah Lebeer

Summary: The study developed a throat spray with live lactobacilli that exhibited several mechanisms of action against respiratory viral infections. Three selected strains showed significant reduction in the cytopathogenic effects of respiratory syncytial virus (RSV), influenza A/H1N1 and B viruses, and HCoV-229E coronavirus in co-culture models. Administration of the throat spray in healthy volunteers confirmed temporary colonization of the throat by metabolically active lactobacilli. The developed spray may be a potential broad-acting live biotherapeutic strategy against respiratory viral diseases.

Article Pediatrics

Antibiotics and uncertainty of diagnosis in viral respiratory infections: Point-prevalence survey across 15 European countries

Malte Kohns Vasconcelos

Article Medicine, General & Internal

Oral Fluvoxamine With Inhaled Budesonide for Treatment of Early-Onset COVID-19 A Randomized Platform Trial

Gilmar Reis, Eduardo Augusto dos Santos Moreira Silva, Daniela Carla Medeiros Silva, Lehana Thabane, Vitoria Helena de Souza Campos, Thiago Santiago Ferreira, Castilho Vitor Quirino dos Santos, Ana Maria Ribeiro Nogueira, Ana Paula Figueiredo Guimaraes Almeida, Leonardo Cancado Monteiro Savassi, Adhemar Dias de Figueiredo Neto, Carina Bitaraes, Aline Cruz Milagres, Eduardo Diniz Callegari, Maria Izabel Campos Simplicio, Luciene Barra Ribeiro, Rosemary Oliveira, Ofir A. Harari, Lindsay A. Wilson, Jamie Forrest, Hinda Ruton, Sheila Sprague, Paula McKay, Christina M. Guo, Gordon H. Guyatt, Craig R. Rayner, David R. Boulware, Nicole Ezer, Todd C. Lee, Emily Gibson McDonald, Mona Bafadhel, Christopher Butler, Josue Rodrigues Silva, Mark J. Dybul, Edward Mills

Summary: This study aimed to determine whether the combination of fluvoxamine and inhaled budesonide would increase treatment effects in a highly vaccinated population. The results showed that the proportion of patients observed in an emergency setting or hospitalized due to COVID-19 was lower in the treatment group than the placebo group, suggesting that the combination treatment can reduce the risk of disease progression.

Article Primary Health Care

Experiences of urine collection devices during suspected urinary tract infections: a qualitative study in primary care

Margaret Glogowska, Caroline Croxson, Christopher Butler, Gail Hayward

Summary: This qualitative study explored women's experiences of urine collection and the use of urine collection devices (UCDs) during a suspected urinary tract infection (UTI). Most women expressed dissatisfaction with their normal urine collection methods but were willing to use UCDs, finding them hygienic and convenient. Potential barriers to UCD use included positioning for sample collection, difficulty due to UTI symptoms, and waste disposal.

Article Infectious Diseases

Point prevalence audit surveys of respiratory tract infection consultations and antibiotic prescribing in primary care before and during the COVID-19 pandemic in Ireland

M. Shah, A. Fleming, T. M. Barbosa, A. W. van der Velden, S. Parveen, A. Vellinga

Summary: This study aims to assess the quality of antibiotic prescribing, the impact of the COVID-19 pandemic, and identify opportunities for antimicrobial stewardship in Ireland. The results showed a significant reduction in antibiotic prescribing during the COVID-19 pandemic, with high prescription rates for bronchitis and tonsillitis. Targeted initiatives to reduce antibiotic prescribing for these conditions and the introduction of point-of-care testing were recommended to support appropriate antibiotic prescribing.

Article Medicine, General & Internal

Effectiveness of spironolactone for women with acne vulgaris (SAFA) in England and Wales: pragmatic, multicentre, phase 3, double blind, randomised controlled trial

Miriam Santer, Megan Lawrence, Susanne Renz, Zina Eminton, Beth Stuart, Tracey H. Sach, Sarah Pyne, Matthew J. Ridd, Nick Francis, Irene Soulsby, Karen Thomas, Natalia Permyakova, Paul Little, Ingrid Muller, Jacqui Nuttall, Gareth Griffiths, Kim S. Thomas, Alison M. Layton

Summary: This study assessed the effectiveness of oral spironolactone for acne vulgaris in adult women. The results showed that spironolactone had significant improvement in acne symptoms and quality of life compared to placebo at 12 weeks and 24 weeks, with no serious adverse reactions reported. This suggests that spironolactone is a useful alternative to oral antibiotics for women with acne.

Article Medicine, General & Internal

Multi-faceted intervention to improve management of antibiotics for children presenting to primary care with acute cough and respiratory tract infection (CHICO): efficient cluster randomised controlled trial

Peter S. Blair, Grace Young, Clare Clement, P. Dixon, Penny Seume, Jenny Ingram, Jodi Taylor, Christie Cabral, Patricia J. Lucas, Elizabeth Beech, Jeremy Horwood, Martin Gulliford, Nick A. Francis, Sam Creavin, Janet A. Lane, Scott Bevan, Alistair D Hay

Summary: This multifaceted intervention for children with respiratory tract infections in primary care did not reduce antibiotic dispensing or increase hospital admissions. However, there was some evidence that the intervention slightly reduced prescribing rates in certain subgroups and situations, but not in a clinically relevant way.

Article Health Care Sciences & Services

Antibiotics for lower respiratory tract infection in children presenting in primary care: ARTIC-PC RCT

Paul Little, Nick A. Francis, Beth Stuart, Gilly O'Reilly, Natalie Thompson, Taeko Becque, Alastair Hay, Kay Wang, Michael Sharland, Anthony Harnden, Guiqing Yao, James Raftery, Shihua Zhu, Joseph Little, Charlotte Hookham, Kate Rowley, Joanne Euden, Kim Harman, Samuel Coenen, Robert C. Read, Catherine Woods, Christopher C. Butler, Saul N. Faust, Geraldine Leydon, Mandy Wan, Kerenza Hood, Jane Whitehurst, Samantha Richards-Hall, Peter Smith, Michael Thomas, Michael Moore, Theo Verheij

Summary: This study aims to evaluate the clinical effectiveness and cost-effectiveness of amoxicillin for uncomplicated lower respiratory tract infections in children. The results show that amoxicillin has no significant impact on clinical symptoms and resource utilization. It is suggested that parents and clinicians need better access to information and communication.

Article Multidisciplinary Sciences

Determining the clinical and cost-effectiveness of nasal sprays and a physical activity and stress management intervention to reduce respiratory tract infections in primary care: A protocol for the 'Immune Defence' randomised controlled trial

Jane Vennik, Adam W. A. Geraghty, Kate Martinson, Lucy Yardley, Beth Stuart, Michael Moore, Nick Francis, Alastair Hay, Theo Verheij, Katherine Bradbury, Kate Greenwell, Laura Dennison, Sian Williamson, James Denison-Day, Ben Ainsworth, James Raftery, Shihua Zhu, Christopher Butler, Samantha Richards-Hall, Paul Little

Summary: Most adults in the UK experience viral respiratory tract infections (RTIs) annually, and certain individuals are at higher risk. Common nasal sprays and digital interventions promoting physical activity and stress management are being tested to reduce the incidence and severity of RTIs. This randomized controlled trial aims to compare the effectiveness and economic impact of these interventions. Recruitment started in December 2020 and is expected to be completed by April 2024.

Article Public, Environmental & Occupational Health

Determinants of life-expectancy and disability-adjusted life years (DALYs) in European and Organisation for Economic Co-operation and Development (OECD) countries: A longitudinal analysis (1990-2019)

Vladimira Varbanova, Niel Hens, Philippe Beutels

Article Infectious Diseases

Serotype 19A and 6C Account for One-Third of Pneumococcal Carriage Among Belgian Day-Care Children Four Years After a Shift to a Lower-Valent PCV

Esra Ekinci, Liesbet Van Heirstraeten, Laura Willen, Stefanie Desmet, Ine Wouters, Helene Vermeulen, Christine Lammens, Herman Goossens, Pierre Van Damme, Jan Verhaegen, Philippe Beutels, Heidi Theeten, Surbhi Malhotra-Kumar, NP Carriage Study Grp

Summary: The switch from PCV13 to PCV10 in Belgium was associated with an increase in carriage of serotypes 19A and 6C in healthy children, leading to the reintroduction of the 13-valent conjugate vaccine.